Vol. 8, Issue 8 (2019)

Author(s):
Sanjesh Kumar and Mansi Singh

Abstract:
Objective: In this study, we evaluated the pharmacological effect of the Centella asiatica in the anxiety disorders with the help of the help of Elevated zero maze and Elevated plus maze apparatus in rats. The present study focuses on the Pharmacological evaluation of the Centella asiatica for anxiolytic activity with its ethanolic extract with the help of the Elevated zero maze and Elevated Plus maze apparatus in rats. For the study, the rats were divided into 4 groups and named or tagged properly. Group-I consisted of the rats that were administered Normal saline (2ml/kg) which served as control group, Group-II consisted of rats that are treated with the standard drug Diazepam (1.0mg/kg) and both the groups were treated 30min. prior to the experiment. Centella asiatica extract was administered at doses of Group-III 200mg/kg (T1) and Group-IV 400mg/kg (T2) body weight. The treated, standard groups are compared with control group and values are represented as the mean± SEM; n=3; P<0.05; P<0.01vs control. The following study found that there was enormous decline in the anxiety levels of the subjects and even the drug helps to replenish the decreased neurotransmitter levels in the brain.