In comparison with the right ventricle, the left ventricle is more muscular, so it’s walls are roughly thicker that allows it performing its pumping function under higher pressure respectively roughly by 5 times that provides sufficient blood ejection into aorta. The left ventricle (LV) takes on higher functional exercise than other parts of the heart and therefore tends more often to have pathologic changes. Hence it becomes clear that clinical indications and prognostic significance will be more intense dependent on the functional state of the LV.
A cause of impaired myocardial contractile function is its remodeling that in its turn may have different extents. Its manifestation depends on neurohormonal activation that is noticed after an infarction, as well as on stronger stretch of LV; the result is heart muscle increased oxygen demand. Neurohormone activation occurs at first for stabilizing of heart activity and blood pressure, but eventually its nature becomes pathological.
On the basis of our results of 3-months observation of rehabilitating patients after myocardial infarction, collecting patients’ complaints, laboratory and instrumental examinations it is possible to make a conclusion about that that there are medications helping to improve myocardium functional state significantly, particularly the left ventricle. One of such medications is carvedilol, which was included in the treatment scheme of patients from the studied group.