Vol. 8, Issue 7 (2019)

Methods: Carrageenan induced paw edema model was used for the in-vivo anti-inflammatory activity of cinnamon oil in female wistar rats. As a standard drug control indomethacin was administered at the dose rate of 10 mg/kg female wistar rats. Rats of control groups were kept untreated. Other three groups were treated with cinnamon oil at the dose rate of 50, 100 and 200 mg/kg b. wt., respectively.

Results: Cinnamon oil showed dose dependent anti-inflammatory effect at various doses in female wistar rats. The anti-inflammatory effect of cinnamon oil was highest at 3h (30.58%) at the dose of 200mg/kg. It was lower than anti-inflammatory effect of standard drug indomethacin at 3h (42.99%).

Conclusion: The highest anti-inflammatory activity was observed at 3-hour post oral administration of cinnamon oil @ 50, 10 and 200 mg/kg b. wt. in female wistar rats.