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Vol. 8, Issue 7 (2019)

Determination of in-vivo anti-inflammatory potential of Cinnamomum zeylanicum oil in female wistar rats

Author(s):
Jaimin A Prajapati, Brijesh R Humbal, Kamlesh A Sadariya, Shailesh K Bhavsar and Aswin M Thaker
Abstract:
Objective: The aim of the present study was to evaluate in vivo anti-inflammatory activity of cinnamon oil (Cinnamomum zeylanicum) following single dose oral administration (50, 100 and 200 mg/kg) in female wistar rats.
Methods: Carrageenan induced paw edema model was used for the in-vivo anti-inflammatory activity of cinnamon oil in female wistar rats. As a standard drug control indomethacin was administered at the dose rate of 10 mg/kg female wistar rats. Rats of control groups were kept untreated. Other three groups were treated with cinnamon oil at the dose rate of 50, 100 and 200 mg/kg b. wt., respectively.
Results: Cinnamon oil showed dose dependent anti-inflammatory effect at various doses in female wistar rats. The anti-inflammatory effect of cinnamon oil was highest at 3h (30.58%) at the dose of 200mg/kg. It was lower than anti-inflammatory effect of standard drug indomethacin at 3h (42.99%).
Conclusion: The highest anti-inflammatory activity was observed at 3-hour post oral administration of cinnamon oil @ 50, 10 and 200 mg/kg b. wt. in female wistar rats.
Pages: 544-547  |  255 Views  71 Downloads


The Pharma Innovation Journal
How to cite this article:
Jaimin A Prajapati, Brijesh R Humbal, Kamlesh A Sadariya, Shailesh K Bhavsar, Aswin M Thaker. Determination of <em>in-vivo</em> anti-inflammatory potential of <em>Cinnamomum zeylanicum</em> oil in female wistar rats. Pharma Innovation 2019;8(7):544-547.

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