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Vol. 8, Issue 7 (2019)

Evaluation of in-vivo anti-inflammatory activity of Syzygium aromaticum oil in male wistar rats

Author(s):
Brijesh R Humbal, Kamlesh A Sadariya, Jaimin A Prajapati, Shailesh K Bhavsar and Aswin M Thaker
Abstract:
Objective: The aim of the present study was to evaluate in vivo anti-inflammatory activity of Syzygium aromaticum oil (clove oil) following single dose oral administration (100, 250 and 500 mg/kg) in male wistar rats.
Methods: The in-vivo anti-inflammatory assay of clove oil was carried out using carrageenan induced paw edema model in male rats. Indomethacin was administered @ 10 mg/kg in standard drug control rats. Rats of control groups were kept untreated and other groups were treated with clove oil @ 100, 250 and 500 mg/kg b. wt., respectively.
Results: Clove oil showed dose dependent anti-inflammatory effect at various doses in wistar rats. The anti-inflammatory effect of clove oil was highest at 3h (35.77%) at the dose of 500mg/kg. It was lower than anti-inflammatory effect of standard drug indomethacin at 3h (41.75%).
Conclusion: Clove oil showed dose dependent anti-inflammatory activity in wistar rats.
Pages: 540-543  |  759 Views  182 Downloads


The Pharma Innovation Journal
How to cite this article:
Brijesh R Humbal, Kamlesh A Sadariya, Jaimin A Prajapati, Shailesh K Bhavsar, Aswin M Thaker. Evaluation of <em>in-vivo</em> anti-inflammatory activity of <em>Syzygium aromaticum</em> oil in male wistar rats. Pharma Innovation 2019;8(7):540-543.

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