Vol. 8, Issue 7 (2019)

Methods: The in-vivo anti-inflammatory assay of clove oil was carried out using carrageenan induced paw edema model in male rats. Indomethacin was administered @ 10 mg/kg in standard drug control rats. Rats of control groups were kept untreated and other groups were treated with clove oil @ 100, 250 and 500 mg/kg b. wt., respectively.

Results: Clove oil showed dose dependent anti-inflammatory effect at various doses in wistar rats. The anti-inflammatory effect of clove oil was highest at 3h (35.77%) at the dose of 500mg/kg. It was lower than anti-inflammatory effect of standard drug indomethacin at 3h (41.75%).

Conclusion: Clove oil showed dose dependent anti-inflammatory activity in wistar rats.