Vol. 8, Issue 7 (2019)

Author(s):
Arun Kumar, Aparna Tiwary and Sudhakar Kaushik

Abstract:
Stroke is one of the major causes of morbidity and mortality in the world and in recent years. To devastating impact of ischemic stroke on society, the researchers continue to seek strategies to achieve better functional recovery in stroke victims. Great advances have been made in understanding the diverse pathophysiology of neuronal cell death induced by ischemic stroke, clinically effective neuroprotective therapies are limited. The objective of this review article is to summarise facts pertaining to ischemic stroke cover all stages of the ischemic cascades, starting with the primary injury until the tissue regeneration and repair stage. This review summarises possible mechanism of current perspective on the use of recombinant tissue plasminogen activator (tPA), antiplatelets, anticoagulants, antihypertensive, free radical scavengers and stains as a therapeutic target in stroke treatment in reducing stroke risk and improving outcomes. Finally, based on present information, an evidence-based perspective about current and future use of treatment of ischemic stroke is presented.