Vol. 8, Issue 7 (2019)

Author(s):
Bhosale Poonam, Hajare SW, Ingole RS, Ingawale MV, Rathod Payal, Hedau MS and Waghmare SP

Abstract:
In the present study, protective effect of Curculigo orchioides (CO) was evaluated against cypermethrin induced hemato-biochemical alterations in male Wistar rats. A total of 24 adult male Wistar rats were divided into four groups of six rats each. Group I (control) received normal diet and water ad-libitum, Group II received cypermethrin (12.5 mg/kg bw) OD, orally in distilled water for 28 days, Group III (Treatment 1) received cypermethrin 12.5 mg/kg bw and CO ethanolic extract (100 mg/kg bw), orally dissolved in distilled water and, Group IV (Treatment 2) received cypermethrin 12.5 mg/kg bw and CO ethanolic extract at the dose of 200 mg/kg bw orally for 28 days. From the results of the study it is observed that cypermethrin exposure caused significant (P≤0.05) decrease in Hb, PCV and TEC values and treatment group showed significant (P≤0.05) improvement in Hb, PCV and TEC values. MCV, MCH, and TLC values were increased significantly (P≤0.05) in cypermethrin treated rats whereas CO showed restoration to normal MCV, MCH, MCHC and TLC values as compared to control group rats. The serum AST, ALT, ALP and creatinine increased significantly (P≤0.05) in cypermethrin alone treated group, however, in CO treatment groups AST, ALT and ALP values seen comparable to normal levels. In conclusion the findings of present study indicated that cypermethrin showed significant alterations in the hematobiochemical parameters in male Wistar rats. Thus in conclusion the extract of CO treatment efficiently protected the cypermethrine induced hematobiochemical alterations in Wistar rats.