Vol. 8, Issue 7 (2019)

Aim & objective: To determine the drug utilisation pattern of anti-diabetic drugs in both outpatients and inpatients in tertiary care hospital.

Materials and methods: A retrospective observational study was carried out in 66 prescriptions of outpatient and 87 cases of inpatients containing anti diabetic drugs were randomly evaluated for prescribing pattern in type 2 diabetes mellitus using WHO indicators like drug class, dosage form, fixed dose combinations, generic and branded drugs and dugs from NLEM (National List Of Essential Medicines) 2018-2019

Results:Out of 66 out patients most of them were male (n=48) out of 87 inpatients most of them were male (n=77) Plasma acetone value positive for 8 patients which indicates ketoacidosis out of 66 out patients 11 patients are prescribed with insulin as a monotherapy, in double therapy metformin + glimepiride (n=22) were the most commonly prescribed one In triple therapy metformin+ glimepiride + insulin (n=12) were the most commonly prescribed one totally 11 ADRs are reported in inpatients. About 58% of patients are un adherence to the prescription.

Conclusion: In this study Biguanides and in sulins are prescribed mostly in outpatients and inpatients. DPP-4 inhibitor is the only newer drug prescribed in our hospital. Out of 153 patients 8 patients having diabetic ketoacidosis. According to Narenjo scale Out of 87 inpatients 11 ADRs are reported in both metformin and glimepiride. According to Morisky’s instrument patient adherence is calculated based on questionnaires, about 58% patients are non adherent with anti-diabetic drugs in both in and out patients, this can be improved by patient counselling. Core indicators are recommended by WHO in type 2 diabetes mellitus patients shows that prescriptions are prescribed in generic than in proprietary names.