Toll Free Helpline (India): 1800 1234 070

Rest of World: +91-9810852116

Free Publication Certificate

Vol. 8, Issue 6 (2019)

Formulation development and evaluation of immediate release tablets containing antihypertensive agent amlodipine besylate and valsartan

Author(s):
Dhananjay Patil, Bhagyashri Sonagra, Rupesh Deore, Anuradha Bhalerao and Vinod Bairagi
Abstract:
The main aim of this study was to formulate the immediate release tablet containing Amlodipine besylate as calcium channel blocker and Valsartan as angiotensin II receptor blocker. The advantage of this combination therapy for hypertension include better blood pressure control by synergistic combination of angiotensin II receptor blocker with calcium channel blocker. The objective of the present study was to formulate and evaluate an oral administrable tablet containing Amlodipine besylate and Valsartan by different granulation technique. The tablets were prepared using different excipients and crospovidone is used as a disintegrant.
The prepared tablets were evaluated for various pre-compression characteristics like angle of repose, bulk density, tapped density, Carr’s index, Hausner's ratio and post-compression characteristics like appearance, weight variation, hardness, thickness, disintegration, friability, In vitro dissolution study etc. The stability studies were carried out for the optimized batch for three months and it showed no significant changes in the physicochemical parameters and in vitro release pattern. The present study concludes that combined pill has the potential to improve the management of hypertensive patients with additional cardiovascular risk factors and reducing prescription costs.
Pages: 1271-1278  |  1009 Views  650 Downloads


The Pharma Innovation Journal
How to cite this article:
Dhananjay Patil, Bhagyashri Sonagra, Rupesh Deore, Anuradha Bhalerao, Vinod Bairagi. Formulation development and evaluation of immediate release tablets containing antihypertensive agent amlodipine besylate and valsartan. Pharma Innovation 2019;8(6):1271-1278.

Call for book chapter