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Vol. 8, Issue 6 (2019)

Simultaneous determination of norfloxacin and metronidazole from combined tablet dosage formulation by spectrophotometry

Author(s):
Pralhad Rege, Kyle Meyer and Neha Kapadia
Abstract:
In present study, a successful attempt has been made to develop a simple, sensitive, accurate and economical Spectrophotometric method for simultaneous estimation of Norfloxacin and Metronidazole in tablet dosage form. The method is based on the simultaneous equations. Norfloxacin and Metronidazole shows absorbance maxima at 275 nm and 325 nm in 0.1N sodium hydroxide, respectively. The linearity was obtained in the concentration range 1 μg / mL to 10 μg / mL for standard N at 275 nm and 2 μg / mL to 20 μg / mL for standard M at 325 nm.. In given method the quantification of the drugs was done by using simultaneous equation method. The results of the analysis have been validated statistically and by assay, recovery studies. Therefore the proposed validated method can be successfully applied for routine quality control analysis and simultaneous determination of norfloxacin and metronidazole in combined drug formulations.
Pages: 975-979  |  492 Views  140 Downloads


The Pharma Innovation Journal
How to cite this article:
Pralhad Rege, Kyle Meyer, Neha Kapadia. Simultaneous determination of norfloxacin and metronidazole from combined tablet dosage formulation by spectrophotometry. Pharma Innovation 2019;8(6):975-979.

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