Vol. 8, Issue 6 (2019)

Objective: To formulate cream containing herbosome using polyherbal extract and determine repellency effect against wild species of Aedes albopictus and black fly.

Methods: Herbosome was prepared using polyherbal extract in various ratios against phosphotidylcholine by rotary evaporation technique. Five formulation of herbosome were prepared. Formulations were optimized on the basis of total flavonoid content. Finally optimized herbosome was incorporated to cream.

Results: The herbosome formulation (F3) contains 92.10% total flavonoid content, so considered as optimized herbosome formulation. Similarly F1 formulation of cream was found satisfactory based on the results of viscosity, spread ability, and wash ability.

Conclusion: The herbs used in preparation of herbosomes were reported to have good repellency activity. Herbosomes of polyherbal extract incorporated into semisolid dosages form cream. The cream formulation demonstrated satisfactory properties suitable for topical application. Usefulness of the optimized cream formulation for repellant effect has to be established on wild species of black fly and Ades albopictus mosquito.