Vol. 8, Issue 6 (2019)

Author(s):
Sakhare Abhaykumar D, Biyani Kailash R and Sudke Suresh G

Abstract:
The objective of present research work was to design and optimize reservoir type transdermal patches of carvedilol. These patches were prepared by solvent casting technique using hydrophilic polymers and polyvinyl pyrrolidone K30 (rate controlling membrane). The patches were characterized for physico- chemical properties and were found within acceptable limits. The in-vitro drug release was performed using Franz diffusion cell for the selection of optimized formulation from all prepared formulations. Formulation R7 was selected as optimized formulation since it shows highest flux for 24 hr and the drug release from all formulations follows zero order release kinetics. Formulation R7 shows excellent correlationship between in- vitro diffusion profile and ex-vivo permeation profile with regression coefficient (r² = 0.999). Formulation R7 was found to be stable for short term stability studies as per International Council of Harmonization (ICH) guidelines. The study demonstrated that the present system has a potential of delivering active across skin in controlled manner with desired systemic activity.