Comparative efficacy of cinnamon extract, Cinnamaldehyde, silver nanoparticles and conjugated silver nanoparticles in attenuation of cadmium induced testicular toxicity
Sathya M and Sakthi Shree K
Cadmium is an environmental contaminant, a known endocrine disruptor and reproductive toxicant, The present study aims to elucidate the comparative efficacy of Cinnamon Extract (CE), Cinnamaldehyde (CA), Silver Nanoparticles (AgNPs) and Conjugated Siver Nanoparticles (CAgNPs) produced by Green synthesis, in attenuating the testicular toxicity induced by Cadmium at a dosage of 200mg/Kg Bodyweight (BW) for a period of 90 days. Six Groups of 4 rats each were selected. One group given saline and treated as control, second group given Cadmium and all the rest of the groups given Cadmium along with the respective Co-administration of CE, CA, AgNPs and CAgNPs. After treatment schedule, samples were collected and biochemical parameters - Glucose, Total Cholesterol and serum Triglyceride as well as hormonal parameters – Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH) and Testosterone (TST) were evaluated along with changes in Histo architecture of Testis. Reduction in body weight (BW), Testicular weight (TW), Glucose Level, total cholesterol and FSH Levels with increase in Triglyceride as well as LH and TST Levels were observed in rats. Deleterious changes in Histopathology of Testis seems to be attenuated to near normalcy on co-administration of the above agents to a certain extent. Of the four, conjugated AgNPs seen to give an effective reversal of Cadmium induced toxic effect.
How to cite this article:
Sathya M, Sakthi Shree K. Comparative efficacy of cinnamon extract, Cinnamaldehyde, silver nanoparticles and conjugated silver nanoparticles in attenuation of cadmium induced testicular toxicity. Pharma Innovation 2019;8(6):73-80.