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Vol. 8, Issue 5 (2019)

Formulation optimization and evaluation of Terbinafine hydrochloride nanoparticles for topical applications

Author(s):
Vimal Kishore and Revathi A Gupta
Abstract:
Objectives: Aim of the present study was to improve bioavailability and targeted drug delivery. Mucoadhesive nanoparticles of terbinafine hydrochloride had been formulated in order to achieve the prolonged retention at the site of application results in less frequent dosing and sustained response.
Methods: The chitosan nanoparticles of terbinafine Hydrochloride was prepared by modified ionic gelation method and optimized by using Box-Behnken Design. The optimized nanoparticles formulation further characterized for the particle size, percentage drug encapsulation efficiency, percentage yield and mucoadhesive strength. The drug permeation behavior of the optimized formulation was studied by using Franz diffusion cell using goat skin and compared with marketed formulation.
Results and conclusion: The nanoparticles size below 100nm was prepared successfully by modified ionic gelation method. The low flux value of terbinafine HCl mucoadhesive nanoparticles as compared to drug suspension and marketed formulation revealed that the nanoparticles permeated through goat skin mucosa in a controlled manner up to 24 hrs, whereas terbinafine suspension and marketed formulation show high permeability over short duration. Thus topical delivery of terbinafine hydrochloride nanoparticles is an efficient tool to improve its bioavailability and therapeutic effect against fungal infections.
Pages: 820-831  |  189 Views  97 Downloads


The Pharma Innovation Journal
How to cite this article:
Vimal Kishore, Revathi A Gupta. Formulation optimization and evaluation of Terbinafine hydrochloride nanoparticles for topical applications. Pharma Innovation 2019;8(5):820-831.

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