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Vol. 8, Issue 5 (2019)

Synthesis, molecular docking studies and in vitro anthelmintic activities of novel substituted pyrazole bearing benzimidazole derivatives

Author(s):
Neetu Soni, Azad Gangwar and Namrta Soni
Abstract:
Nitrogen containing heterocycles have got special attention in pharmaceutical chemistry due to their excellent medicinal potential. A novel series of substituted pyrazoline derivatives of benzimidazole have been synthesized by the reaction of substituted chalcones with hydrazine hydrate and phenyl hydrazine hydrate. In correlation to anthelmintic activity, compounds are subjected to molecular docking studies for the binding to b-Tubulin, target protein elite to the parasites. All the products were assayed for anthelmintic activity against Pheretima posthuma using albendazole as reference compounds. Out of the twelve synthesized derivatives, five compounds (6d, 6c, 7a, 7c, 7d) showed anthelmintic activity in dose-dependent manner giving shortest time of paralysis and death with different concentrations of the derivatives. Among these two derivatives, 6c and 6d showed superior activity. In molecular docking study also, compounds showed minimum binding energy and have good affinity toward the active pocket thus, they may be considered as good inhibitor of b-Tubulin.
Pages: 327-332  |  400 Views  68 Downloads


The Pharma Innovation Journal
How to cite this article:
Neetu Soni, Azad Gangwar, Namrta Soni. Synthesis, molecular docking studies and <em>in vitro</em> anthelmintic activities of novel substituted pyrazole bearing benzimidazole derivatives. Pharma Innovation 2019;8(5):327-332.

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