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Vol. 8, Issue 5 (2019)

Design, synthesis and characterization of novel benzothiazole derivatives containing thiazolidine-2, 4-dione for anti-cancer screening

Author(s):
Aleti Rajareddy and M Srinivas Murthy
Abstract:
A novel synthetic methodology for preparation of Novel benzothiazole derivatives containing thiazolidine-2, 4-dione were prepared by knoevenagel condensation reaction, Schiff’s base and manich base reaction. The newly synthesized compound was characterized using 1H-NMR, FT-IR and MASS spectrometry. The anticancer activity of the synthesized compounds was evaluated by tube dilution method. All the synthesised compounds were carried out the in vitro Anti-cancer activity by MTT Assay. The compounds 4a, 4f and 4h exhibited good anticancer activity against breast (MCF-7) cancer cell lines at a concentration of 0.5 mg / mL-1.
Pages: 175-180  |  787 Views  138 Downloads


The Pharma Innovation Journal
How to cite this article:
Aleti Rajareddy, M Srinivas Murthy. Design, synthesis and characterization of novel benzothiazole derivatives containing thiazolidine-2, 4-dione for anti-cancer screening. Pharma Innovation 2019;8(5):175-180.

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