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Vol. 8, Issue 4 (2019)

Haemato - biochemical evaluation of detomidine in cattle

Gnanasekar R, Varadharajan A and Kothandaraman S
Haemato - biochemical evaluation of detomidine - a sedative drug, at different dose rates was studied in cattle. The study was conducted in 18 cattle. The cattle were randomly divided into 3 groups of 6 cattle each. 10, 20 and 30 mg/kg body weight detomidine given intravenously to the group I, II and III respectively. Haematological parameters like haemoglobin, total erythrocyte count, packed cell volume, total leucocyte count and differential count and biochemical parameters like plasma cortisol, blood glucose, total serum protein, aspartate aminotransferase, alanine aminotransferase, blood urea nitrogen and creatinine were studied. The data were collected before sedation, at peak sedation, after recovery and after taking feed and water. Total erythrocyte count, haemoglobin and packed cell volume values were reduced significantly at peak sedation. Total leucocyte count and differential count showed no significant change at any stage of the study. Blood glucose level increased significantly in a dose dependent manner at peak sedation and the increase continued upto after recovery. Plasma cortisol level was not induced by detomidine. Other parameters showed only non significant changes after detomidine administration.
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The Pharma Innovation Journal
How to cite this article:
Gnanasekar R, Varadharajan A, Kothandaraman S. Haemato - biochemical evaluation of detomidine in cattle. Pharma Innovation 2019;8(4):923-926.

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