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Vol. 8, Issue 4 (2019)

Pathological studies and therapeutic management by vincristine sulphate for oral tumours in bovine

Author(s):
Sandeep Kumar, Ranbir Singh Bisla, Prem Singh and KK Jakhar
Abstract:
Oral tumour may arise at different sites of the oral cavity with diverse predisposing factors, prevalence and treatment outcomes. Tumours of odontogenic origin in domestic animals are rare but interesting tumours that present several challenges to accurate diagnosis. The present study was carried out on eight cattle and buffaloes had tumourous growth in oral cavity. Radiographic examination was helpful to observe the invasiveness of tumour, osteolytic changes, teeth displacement, calcification or any other changes. Histopathological examination revealed oral tumours in bovine were benign in nature and fibroma was the most common tumour. Vincristine sulphate was used at the dose rate of 0.75mg/m2 body surface area intravenously at weekly interval for 4 to 6 times for treatment of these oral tumours. Supportive therapy included administration of liver tonics, vitamin C and B-complex in routine doses. Only two animals showed recovery which had small size tumourous growths of fibroma origin. The results showed that vincristine sulphate alone as a chemotherapeutic agent may give promising result in small size tumourous growth from fibroma origin but large tumourous growth should be debulked by surgery before chemotherapy.
Pages: 836-839  |  378 Views  87 Downloads


The Pharma Innovation Journal
How to cite this article:
Sandeep Kumar, Ranbir Singh Bisla, Prem Singh, KK Jakhar. Pathological studies and therapeutic management by vincristine sulphate for oral tumours in bovine. Pharma Innovation 2019;8(4):836-839.

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