Vol. 8, Issue 4 (2019)
Histopathological changes in liver and heart of diclofenac induced visceral gout in broilers and its amelioration with ayurvet product
Kanakuntla Sandhyarani, D Madhuri, M Jeevanalatha and K Dhanalakshmi
A study was conducted to examine the gross and histopathological changes in the kidney of diclofenac induced visceral gout in day old broiler chicks and its amelioration by an ayurvet product. A total of 125 healthy day old male broiler chicks (Vencobb strain) were divided into 5 groups consisting of 25 birds in each. The Group 1 birds served as control and Group 2 served as diclofenac toxic control (@ 30 ppm in feed) for 14 days. Group 3 birds were treated with ayurvet product (AV/AUP/16 @ 5ml/day/100 birds for 0-2 weeks, 10 ml/day/100 birds for 2-4 weeks, 20 ml/day/100 birds for 4-6 weeks) upto 42 days. Group 4 were treated with diclofenac for 14 days along with ayurvet product from 1st to 42nd day. Group 5 birds were treated with diclofenac for 14 days followed by ayurvet product from 15th day to 42nd day. These birds were sacrificed on 14th, 28th and 42nd day and observed congested, enlarged liver and pericardium along with white chalky deposits of urate crystals on the visceral surface in diclofenac treated groups and presence of light pink coloured urate crystals as radiating pattern in liver parenchyma (H&E stain). These urate crystals were black in color with De Galantha’s stain. The histopathological changes were reduced in ayurvet product treated groups.
How to cite this article:
Kanakuntla Sandhyarani, D Madhuri, M Jeevanalatha, K Dhanalakshmi. Histopathological changes in liver and heart of diclofenac induced visceral gout in broilers and its amelioration with ayurvet product. Pharma Innovation 2019;8(4):250-255.