There were examined 32 patients aged 22-44 years for some epigenetic mechanisms of the GP development; of them: 12 (by 6 men and women) were somatically and dentally healthy (group I, control) and 20 (by 10 men and women) patients with initial-I degree of the GP (group II). In cytological preparations of buccal epitheliocytes of the mucous membrane of oral cavity (MMOC) stained with aceto-orcein, 100 nucleus-containing epitheliocytes were examined using “Axioskop” microscope, Zeizz company (magnification: x 1000). Their cytomorphometric characteristics were studied: perimeter and area of the cell, perimeter and area of the nucleus, and the ratio of the area of the nucleus to the area of the cell before and after the complex therapy. All patients were performed initial periodontal therapy, local medicional treatment using the solution “Phytodent” and ointment “Thiotriazoline”, and endogenously “Thiotriazoline” was prescribed in tablets, as well as mineral complex “Calcemine”.
It wasdetermined that in all patients with GP of the chronic course of initial-I degree compared with healthy ones, the cytomorphometric indices of MMOC of epithelial cells significantly reduce, namely: perimeter and area of cells and nuclei (p=≤0.05; p=0.01). Due to the use of the methodof complex treatment developed by us, they significantly increased (p1<0.05; p1<0.01; p1<0.005), practically reaching the data of healthy persons (p>0.05). The gender peculiarities of the effectiveness of the complex treatment of the GP were in the more pronounced positive dynamics of morphometric parameters of epithelial cells and their nuclei in men, the increase of which was probable (p1<0.05; p1<0.01; p1=0.001), compared with that in women; these indicators’ growth in women was insignificant (p1>0.05). The normalization of cells and nuclei parameters apparently occurred due to the pharmacotherapeutic effect of the used medicines, in particular, “Thiotriazoline”, which positively affects the links of cellular metabolism that we’ve studied by improving the chromatin compaction in the karyoplasm.