Vol. 8, Issue 4 (2019)

Author(s):
Yogesh A Gurav and Fahim J Sayyad

Abstract:
Lamotrigine is exclusively dissolved and absorbed from upper region of gastrointestinal tract. Therefore, the present study was aimed to design a regioselective delivery system of lamotrigine to enhance its bioavailability. The study explores utilization of novel polymer, curdlan gum in the design of regioselective drug delivery system and its comparison with HPMC K100M. Lamotrigine tablets were prepared by direct compression and evaluated for parametric tests, floating ability, swelling index and release kinetic study. The tablets pass the parametric tests as per Indian Pharmacopoeia and shows significant floating ability with low floating lag time. Formulation F4 was selected as optimized formulation and was found to be stable for short term stability study as per International Council Harmonization guidelines. Hence, the study successfully explores curdlan gum to achieve the objective of regioselective drug delivery system.