Vol. 8, Issue 3 (2019)
Haemato-biochemical and anti-oxidant alterations in chicks of visceral gout induced by diclofenac and its amelioration by ayurvet product
Kanakuntla Sandhyarani, D Madhuri, M Jeevanalatha and K Dhanalakshmi
Visceral gout assumes prime economic importance in poultry industry due to increased incidence causing production losses and mortality. The present study was carried out to study the efficacy of ayurvet product in gout induced broilers in relation with haemato biochemical and anti-oxidant values. A total of 125 healthy day old male broiler chicks (Vencobb strain) were divided into 5 groups consisting of 25 birds in each. The Group 1 birds served as control and Group 2 served as diclofenac toxic control (@ 30 ppm in feed) for 14 days. Group 3 birds were treated with ayurvet product (AV/AUP/16 @ 5ml/day/100 birds for 0-2 weeks, 10 ml/day/100 birds for 2-4 weeks, 20 ml/day/100 birds for 4-6 weeks) upto 42 days. Group 4 were treated with diclofenac for 14 days along with ayurvet product from 1st to 42nd day. Group 5 birds were treated with diclofenac for 14 days followed by ayurvet product from 15th day to 42nd day. Haemato biochemical parameters were analyzed on 14th, 28th and 42nd day. Results showed significant (P<0.05) decrease in the values of Hb, TEC and PCV whereas TLC count was increased in diclofenac treated groups i.e groups 2, 3 and 4 upto 14 days when compared to control. There was a significant (P<0.05) elevated levels of biochemical parameters AST, ALT, ALP, UCCCCric acid and creatinine noticed in diclofenac treated groups indicated liver and renal damage. Antioxidant profile showed decreased GSH and increased TBARS in kidney and liver tissue in group 2 birds. An improvement in respect of haemato-biochemical and antioxidant profile was observed in group 4 and 5 birds.
How to cite this article:
Kanakuntla Sandhyarani, D Madhuri, M Jeevanalatha, K Dhanalakshmi. Haemato-biochemical and anti-oxidant alterations in chicks of visceral gout induced by diclofenac and its amelioration by ayurvet product. Pharma Innovation 2019;8(3):414-418.