Vol. 8, Issue 3 (2019)
Formulation and evaluation of oral Disintegrating tablets of Zingiber officinale
Puppala Raman Kumar, Rachakonda Bhargavi, Shaik Sameena, Vallam Setty Anil Kumar, Katta Subhash Kumar and Channamallu Sambasiva Rao
Oral dissolving drug delivery system offers a solution for those patients having difficulty in swallowing. Zingiber officinale, has been used for medicinal purpose since antiquity to treat motion sickness, pregnancy, and cancer-chemotherapy-induced vomiting, mild stomach upset, cough, chronic bronchial problems, and low-grade infections of all kinds and anorexia condition. This work investigates the possibility of developing Zingiber officinale oral disintegrating tablets allowing fast, reproducible dissolution in oral cavity; thus bypassing first pass metabolism. The oral disintegrating tablets were prepared by Direct Compression method. Prepared tablets were evaluated for Pre and Post Compressional parameters like flow properties, hardness, Friability, Disintegration studies, Dissolution studies, accelerated stability studies. The different exciepients such as Lactose Anhydrous, MCC PH-102, Pregelatinized Starch, Cros Carmellose Sodium, Sodium Starch Glycolate, Cross Povidone, Sodium Sacharin, Aerosil, Magnesium Stearate were explored individually and in combination with each other for the formation of tablets. Among all the formulations the wetting time and disintegration time both are less for the formulation containing croscarmellose sodium (8%w/w) as super disintegrant (F6). The dissolution rate of the optimized formulations (F6) was found to be higher when compared to other formulations. Among the all the formulation F6 was found to be promising ODT formulation.
How to cite this article:
Puppala Raman Kumar, Rachakonda Bhargavi, Shaik Sameena, Vallam Setty Anil Kumar, Katta Subhash Kumar, Channamallu Sambasiva Rao. Formulation and evaluation of oral Disintegrating tablets of<em> Zingiber officinale</em>. Pharma Innovation 2019;8(3):150-155.