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Vol. 8, Issue 3 (2019)

Pharmacological screening of Griseofulvin loaded solid lipid nanoparticles for improved oral delivery of poorly water soluble drug

Author(s):
Hitesh Kumar, Ashok Kumar Rajpoot, Saurabh Sharma and Arvind Kumar
Abstract:
In current research, Griseofulvin-loaded solid lipid nanoparticles (SLNs) were prepared using glyceryl monostearate (GMS) as a lipid by hot homogenisation method. Griseofulvin was selected as a model drug for BCS (Biopharmaceutics Classification system) Class II drugs. Solubility is a major concern for the improvement of oral bioavailability for poorly water soluble drugs as in case of BCS class II. The SLN batches were optimized based on average particle size, drug entrapment efficiency, drug loading and percentage yield. The optimized SLN composition was characterized in terms of particle shape and size, drug entrapment efficiency and drug loading. In-vivo antifungal activity against Microsporum canis for optimized batch was carried out using albino rat model for the treatment of dermatophytosis. The bioavailability of drug after oral administration in albino rats was found to be significantly higher as compared to the conventional dosage form of drug. A complete mycological and clinical cure was observed during the study in M. canis infected albino rats. Griseofulvin loaded SLNs were administered orally once daily in infected rats for 7 days. It can be concluded from our study that SLNs improves the oral delivery of poorly water soluble drugs like griseofulvin that belongs to BCS Class II drugs.
Pages: 55-58  |  965 Views  137 Downloads


The Pharma Innovation Journal
How to cite this article:
Hitesh Kumar, Ashok Kumar Rajpoot, Saurabh Sharma, Arvind Kumar. Pharmacological screening of Griseofulvin loaded solid lipid nanoparticles for improved oral delivery of poorly water soluble drug. Pharma Innovation 2019;8(3):55-58.

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