Vol. 8, Issue 3 (2019)

Author(s):
Rajesh A, Doss A, Tresina PS and Mohan VR

Abstract:
In-vitro anticancer activity of four angiosperm plants Crotalaria longipes, Petiveria alliacea, Caralluma umbellata, Niebuhria apetala and a pteridophyte plant Marsilea quadrifolia against MCF-7, MDA-MB468 and MDA-MB231 cell lines was studied. During the present investigation methanol extracts of selected plants were prepared using soxhlet apparatus. Preliminary phytochemical studies revealed the presence of alkaloid, flavonoid, saponin, steroid, phenol, tannin, glycoside and terpenoid. In-vitro anticancer activity of selected plants extracts at various concentrations (50-250 mg/ml) was studied against the chosen cell line using MTT assay. The methanol extract of Crotalaria longipes (aerial part) exhibited highest percentage of inhibition against MCF-7 cell line whereas methanol extract of Niebuhria apetala (whole plant) showed highest percentage of inhibition against MDA-MB468 cell line. Similarly the methanol extract of Caralluma umbellata (whole plant) exhibited highest percentage of inhibition against MDA-MB231 cell line with efficient IC50 values.