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Vol. 8, Issue 2 (2019)

Propylene glycol as a prophylactic agent for prevention of sub clinical ketosis in buffaloes

Randhir Singh, SNS Randhawa and CS Randhawa
Twenty one buffaloes were divided equally into three groups of seven animals each based on results of metabolic profile screening i.e., Group I: Healthy {Pre-partum Non esterified fatty acid (NEFA) levels at close up dry stage (CUD) ≤0.4mmol/L}; Group II (positive control): Pre-partum NEFA levels at CUD stage ≥0.4mmol/L and Group III: NEFA levels at CUD stage ≥0.4mmol/L and supplemented with oral propylene glycol @250 ml once a day for 5 days. Sampling was again done at fresh stage of transition period to evaluate the efficacy of PG as a prophylactic measure to prevent development of SCK in transition buffaloes.Results revealed significant increase in mean PCV percentage from 37.87±1.48% to 42.79±1.21% after propylene glycol administration in group III. Beta hydroxyl butyric acid (BHBA) levels increased significantly in group II from CUD (0.76±0.03 mmol/L) to fresh stage (1.49±0.03 mmol/L) and were significantly higher than PG supplemented group (0.90±0.12 mmol/L) at fresh stage. Non esterified fatty acid (NEFA) recorded non significant increase and decrease in group II and PG supplemented group, respectively. Five out of seven buffaloes, which were administered PG @ 250 ml /day for 5 days orally, crossed transition period uneventfully, whereas, only two buffaloes developed SCK after parturition at fresh stage. All the seven buffaloes in group II (positive control) developed SCK after parturition.
Pages: 582-586  |  386 Views  69 Downloads

The Pharma Innovation Journal
How to cite this article:
Randhir Singh, SNS Randhawa, CS Randhawa. Propylene glycol as a prophylactic agent for prevention of sub clinical ketosis in buffaloes. Pharma Innovation 2019;8(2):582-586.

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