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Vol. 8, Issue 2 (2019)

Evaluation of hepatoprotective and nephroprotective activity of methanolic extract of Cleome viscosa and Cleome gynandra in STZ-induced diabetic rats

Author(s):
Benne Lakshmi Narsimhulu, Yarrappagaari Suresh, Gutha Rajasekar, Thopireddy Lavanya, Gundala Harold Philip, Syed Siraj Mohiyuddin and Saddala Rajeswara Reddy
Abstract:
Cleome is the largest genus in Capparaceae, with over 200 annual herb and shrub species widely circulated in pantropical and subtropical areas of the world. It is used in Ayurveda and other systems of remedy to cure several diseases, such as liver disease, chronic painful joints and mental disorders. It is used as a source of vitamin-C and iron and as a green leafy vegetable in poorer division of the peoples. To evaluate the hepatoprotective and nephroprotective activity of MeCV (methanolic extract of Cleome viscosa) and MeCG (methanolic extract of Cleome gynandra) against streptozotocin (STZ)-induced liver and kidney damage in diabetic rats. The hepatoprotective and nephroprotective activity of MeCV and MeCG were evaluated in rat serum, hepatic tissue injury markers alanine amino transaminase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and total bilirubin assays were performed. The kidney injury serum markers urea and creatinine levels were also determined. Our results indicated that, oral treatment with MeCV and MeCG at dose of 400 mg/k.g b.w to diabetic rats was significantly reduced the levels of AST, ALT, ALP, total bilirubin, urea and creatinine compared with diabetic control rats. The MeCV (400 mg/k.g b.w) was showed highest hepatoprotective and nephroprotective activity the MeCV (400 mg/k.g b.w). These results suggest the potential effect of MeCV extract as a hepatoprotective and nephroprotective agent towards-STZ induced liver and kidney damage.
Pages: 574-581  |  177 Views  8 Downloads
How to cite this article:
Benne Lakshmi Narsimhulu, Yarrappagaari Suresh, Gutha Rajasekar, Thopireddy Lavanya, Gundala Harold Philip, Syed Siraj Mohiyuddin, Saddala Rajeswara Reddy. Evaluation of hepatoprotective and nephroprotective activity of methanolic extract of <em>Cleome viscosa</em> and <em>Cleome gynandra</em> in STZ-induced diabetic rats. Pharma Innovation 2019;8(2):574-581.
The Pharma Innovation Journal