Vol. 8, Issue 2 (2019)

Author(s):
PK Lakshmi, Thaslim begum and K Vidya

Abstract:
The objective of present work is to study the permeation effect of fixed oils taking poorly water soluble aceclofenac as model drug. Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) analogue of diclofenac, it is used for the relief of pain and inflammation in rheumatoid arthritis, osteoarthritis and ankylosing spondylitis. Oils as permeation enhancers are substances that interact with the major constituents of skin barrier, stratum corneum, to promote penetration of drugs into skin. In this study three types of fixed oils (olive oil, coconut oil and sesame oil) were used in two different concentrations (1% and 5%). Xanthan gum in two different concentrations was used as gelling agents. The gels were evaluated for several physico-chemical parameters. All the formulations have shown good physicochemical properties. Ex-vivo diffusion studies showed 90% drug release in 8 hrs. Anti-inflammatory studies on rats and skin irritations studies were performed. The F1 formulation was stable at room temperature for one month.