Vol. 8, Issue 2 (2019)
Pharmacokinetic study of Meloxicam in poultry following multiple doses by intramuscular administration
Preeti Bisht, AH Ahmad, Alok Mishra, Manu Jaiswal and Narendra Kumar
The present study was undertaken to investigate the pharmacokinetics and tissue residue study of meloxicam at a dose rate of 0.5 mg/kg body weight in poultry (n=8) following multiple (5) doses intramuscular administration. The concentration of meloxicam in plasma and tissue of these animals were analysed by High-performance liquid chromatography (HPLC) with Ultra Violet (UV) detector. Following multiple doses i.m. administration volume of distribution, clearance, area under curve (AUC) and elimination half-life were estimated after first dose was 194.38 ml.kg-1, 57.19 ml.h-1.kg-1, 8.91 h.µg.ml-1 and 2.42h, respectively and 189.32 ml.kg-1, 67.56 ml.h-1.kg-1, 8.32 h.µg.ml-1 and 2.18h after the last dose. Residue of meloxicam was not found in kidney, liver and muscle up to 48 hour post administration of meloxicam.
How to cite this article:
Preeti Bisht, AH Ahmad, Alok Mishra, Manu Jaiswal, Narendra Kumar. Pharmacokinetic study of Meloxicam in poultry following multiple doses by intramuscular administration. Pharma Innovation 2019;8(2):189-191.