Vol. 8, Issue 2 (2019)

Author(s):
Preeti Bisht, AH Ahmad, Alok Mishra, Manu Jaiswal and Narendra Kumar

Abstract:
The present study was undertaken to investigate the pharmacokinetics and tissue residue study of meloxicam at a dose rate of 0.5 mg/kg body weight in poultry (n=8) following multiple (5) doses intramuscular administration. The concentration of meloxicam in plasma and tissue of these animals were analysed by High-performance liquid chromatography (HPLC) with Ultra Violet (UV) detector. Following multiple doses i.m. administration volume of distribution, clearance, area under curve (AUC) and elimination half-life were estimated after first dose was 194.38 ml.kg^-1, 57.19 ml.h^-1.kg^-1, 8.91 h.µg.ml^-1 and 2.42h, respectively and 189.32 ml.kg^-1, 67.56 ml.h^-1.kg^-1, 8.32 h.µg.ml^-1 and 2.18h after the last dose. Residue of meloxicam was not found in kidney, liver and muscle up to 48 hour post administration of meloxicam.