Vol. 8, Issue 12 (2019)

Author(s):
Jeet Gandhi, Disha Suthar, Hetal K Patel, Pragna Shelat and Punit Parejiya

Abstract:
Exploration of natural resources from biological metabolites of plants as an alternative to synthetic chemical moieties has proved to emerge as an ailment to various disorders. One of such are essential oils from plants that are belied to have immense medicinal values and have a potential to treat various disorders. One of a kind is lemongrass oil essential oil which is believed to have excellent mosquito repellent activity, perfumery and reported to have strong antifungal property. The objective of present study is to develop and characterize the topical micro emulsion based formulation containing lemon grass oil. The lemongrass oil formulation developed using pseudo ternary phase diagram and optimized by D-optimal design possessing 1.10% of oil, 6.1% of Smix and 91.3% of water was clear transparent light to pale yellow microemulsion with globule size of 14.60 ± 0.31 nm, zeta potential of 0.94 mV and PDI value 0.00133 indicating a stable microemulsion. The light to pale yellow coloured microemulsion based gel showed a drug release of 99.63 ± 0.41% within 180 minutes with retention of drug in skin layers of about 64.99 ± 0.42% and on the skin about 16. 39 ± 0.25% after 12 hours indicating the retention of drug at site of action. The skin irritation study and stability study indicated a non-irritant and stable MBG formulation at 40°C/75% RH for 6 months. Hence it can be said that the lemongrass oil loaded microemulsion based formulation can be used for treatment of fungal infections.