Vol. 8, Issue 12 (2019)

Materials and Methods: 96 patients with HF of ischemic genesis were observed. The spontaneous production of interleukin 1b (IL-1b), interleukin 6 (IL-6), and interleukin 10 (IL-10) by monocytes/macrophages in vitro was detected by ELISA method.

Results: The in vitro spontaneous production of proinflammatory cytokines IL-1b and IL-6 by monocytes/macrophages in patients with HF was significant higher and anti-inflammatory IL-10 was lower than in control group. The progression of HF caused to increase of spontaneous production by monocytes/macrophages of IL-1b and IL-6 but decrease of IL-10.

Conclusion: The monocytes/macrophages in patients with ischemic HF are in condition of chronic activation which manifests of overproduction of proinflammatory cytokines and poor secretion of anti-inflammatory IL-10.