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Vol. 8, Issue 12 (2019)

in vitro production of cytokines by monocytes/macrophages in patients with chronic heart failure

Author(s):
Sergiy Fedorov, Irena Kozlova and Ulyana Chernyaha
Abstract:
Many studies showed an important role of inflammation in heart failure (HF). Monocytes/macrophages are main cells take part in immune response. The purpose of study was to investigate spontaneous cytokines production by monocytes/macrophages in patient with chronic heart failure of ischemic origin.
Materials and Methods: 96 patients with HF of ischemic genesis were observed. The spontaneous production of interleukin 1b (IL-1b), interleukin 6 (IL-6), and interleukin 10 (IL-10) by monocytes/macrophages in vitro was detected by ELISA method.
Results: The in vitro spontaneous production of proinflammatory cytokines IL-1b and IL-6 by monocytes/macrophages in patients with HF was significant higher and anti-inflammatory IL-10 was lower than in control group. The progression of HF caused to increase of spontaneous production by monocytes/macrophages of IL-1b and IL-6 but decrease of IL-10.
Conclusion: The monocytes/macrophages in patients with ischemic HF are in condition of chronic activation which manifests of overproduction of proinflammatory cytokines and poor secretion of anti-inflammatory IL-10.
Pages: 193-195  |  551 Views  53 Downloads


The Pharma Innovation Journal
How to cite this article:
Sergiy Fedorov, Irena Kozlova, Ulyana Chernyaha. <em>in vitro</em> production of cytokines by monocytes/macrophages in patients with chronic heart failure. Pharma Innovation 2019;8(12):193-195.

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