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Vol. 8, Issue 12 (2019)

Simultaneous determination of furazolidone and metronidazole in combined drug formulation by a simple electro analytical technique

Author(s):
Wagh VM, Sathe PA and Rege PV
Abstract:
In present study, a successful attempt has been made to develop a simple method for the simultaneous determination of Furazolidone and Metronidazole using Differential Pulse Voltammetry (DPV) technique. Quantification of Furazolidone and Metronidazole was done in Britton-Robinson Buffer of pH 4.25 using 1M KCl as a supporting electrolyte. Both Furazolidone and Metronidazole exhibit reduction cathodic peak in given pH with peak potential at -0.06 V for Furazolidone and -0.22 V for Metronidazole vs. S.C.E. 0.1N CH3COOH was used as Solvent for the analysis. The parameters used for the method validation are linearity, accuracy, precision, robustness, ruggedness, LOD and LOQ. Proposed method was found to be simple, precise, and accurate and can be successfully applied for routine quality control analysis and simultaneous determination of Furazolidone and Metronidazole in combined drug formulations.
Pages: 132-138  |  174 Views  6 Downloads
How to cite this article:
Wagh VM, Sathe PA, Rege PV. Simultaneous determination of furazolidone and metronidazole in combined drug formulation by a simple electro analytical technique. Pharma Innovation 2019;8(12):132-138.
The Pharma Innovation Journal