Vol. 8, Issue 12 (2019)

Author(s):
Wagh VM, Sathe PA and Rege PV

Abstract:
In present study, a successful attempt has been made to develop a simple method for the simultaneous determination of Furazolidone and Metronidazole using Differential Pulse Voltammetry (DPV) technique. Quantification of Furazolidone and Metronidazole was done in Britton-Robinson Buffer of pH 4.25 using 1M KCl as a supporting electrolyte. Both Furazolidone and Metronidazole exhibit reduction cathodic peak in given pH with peak potential at -0.06 V for Furazolidone and -0.22 V for Metronidazole vs. S.C.E. 0.1N CH₃COOH was used as Solvent for the analysis. The parameters used for the method validation are linearity, accuracy, precision, robustness, ruggedness, LOD and LOQ. Proposed method was found to be simple, precise, and accurate and can be successfully applied for routine quality control analysis and simultaneous determination of Furazolidone and Metronidazole in combined drug formulations.