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Vol. 8, Issue 11 (2019)

Microwave-assisted synthesis, anti-bacterial and anti-ammator activity of 3-(Benzo[d]thiazol-2-ylimino)-1-((e)-3-(phenyl) acryloyl) indolin-2-one novel Chalcone derivatives

Author(s):
Vamsee Krishna Reddy K, Madhusudhan Raju R and Maneshwar T
Abstract:
Novel Chalcones is considered as an important chemical for the synthesis of various physiological significance and pharmacological utilized molecules. Traditionally, chalcones are prepared by Claisen-Schmidt condensation. The structures of the newly synthesized compounds (3a-3o) were elucidated by IR, 1H-NMR, Mass spectroscopy. All the synthesized compounds (3a-3o) screened for their anti-bacterial activity and anti-inflammatory. Anti bacterial activity of 3b, 3c, 3i and 3o showed more activity and 3d, 3j, 3m and 3n showed less activity when compare with streptomycin. From anti-inflammatory evaluations, dose level of 50mg/kg of test compounds reported significantly higher activity when compared to dose level of 20 mg/kg. Moreover, compound 3d, 3g, 3j and 3o resulted in similar anti-inflammatory activity when compared with Celecoxib.
Pages: 316-320  |  211 Views  34 Downloads


The Pharma Innovation Journal
How to cite this article:
Vamsee Krishna Reddy K, Madhusudhan Raju R, Maneshwar T. Microwave-assisted synthesis, anti-bacterial and anti-ammator activity of 3-(Benzo[d]thiazol-2-ylimino)-1-((e)-3-(phenyl) acryloyl) indolin-2-one novel Chalcone derivatives. Pharma Innovation 2019;8(11):316-320.

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