Vol. 8, Issue 11 (2019)

Author(s):
I Hemanth, HD Narayanaswamy, ML Satyanarayana, Suguna Rao, KV Jamuna and Prakash Nadoor

Abstract:
Non-target organ toxicities associated with chemotherapy has been a major setback in the clinical usage of many efficient anticancer drugs. In similar terms, imatinib mesylate, an important member of Tyrosine kinase inhibitor class of drugs has also been associated with vital organ toxicity. Grape seed proanthocyanidins were popular chemoprotective agents against various drug/chemical induced toxicities with proven anti-oxidant mechanisms. In this context, the present study was undertaken to investigate the ameliorative efficacy of GSPs against imatinib induced toxicity in Wistar male rats through histopathological evaluation. The results indicated significantly pronounced lesions of toxicity among drug positive control animals, especially involving the heart, liver and kidneys. GSPs concurrently administered group, however manifested similar lesions of milder intensity, suggesting the ameliorative and chemoprotective efficiency of GSPs against imatinib mesylate induced non-target toxicity.