Vol. 8, Issue 1 (2019)
Protective activity of Guduchi and green tea extract on nicotine-induced toxicity in mice
Dr. Romsha Singh and Kalpana Singh
This study was designed to observe the effects of nicotine on various hematological parameters in adult male mice. A total of 30 mice were divided into six groups; control (n=6) and test groups II, III, IV, V, VI (n=6 comprise in each group). After treatments blood was collected on 0th, 30th and 60th days. Hematological parameters were assessed by using bioanalyzer. Statistical analysis was performed for comparison between the groups by using Dunnett’s test. The white blood cells (WBC) was found significantly higher in a nicotine treated group compared to control group, while the significant decrease was observed in hemoglobin and hemocrait and platelets in the nicotine treated group. In contrast the differential count viz. neutrophil, eosinophil, monocyte, lymphocyte, basophil were found significant (p≤0.05) compared to control group and test groups II, III, IV, V and V respectively. It is concluded that nicotine administration in mice resulted in toxic effects on various hematological parameters. Green tea and guduchi helps more to wakeup immune system and boost the body of person who regularly consume nicotine.
How to cite this article:
Dr. Romsha Singh, Kalpana Singh. Protective activity of Guduchi and green tea extract on nicotine-induced toxicity in mice. Pharma Innovation 2019;8(1):650-656.