Vol. 8, Issue 1 (2019)

Author(s):
Robin, Pooja Kundu, Nikita, Vikash Sharma, Vivek Jangra and SK Jain

Abstract:
Cypermethrin and deltamethrin are synthetic pyrethroid insecticide used for pest control in agriculture and as an acaricide in man and animals. The combined exposure of cypermethrin and deltamethrin was given in adult male Wistar rats and their amelioration by Withania somnifera and resveratrol on histology of liver and kidney was investigated upto 14 and 28 days. The combined treatment of cypermethrin and deltamethrin caused significant changes in liver viz. congestion, mild perivascular reaction, mild fatty change and sinusoidal dilation and in kidney viz. hypercellularity in glomeruli and hyaline degenerative change in parietal layer of glomerulus in 14 days study while focal area of necrosis of hepatocytes with mild infiltration of mononuclear cells in liver and focal interstitial nephritis with congestion and infiltration of mononuclear cells in kidney in 28 days study. In the cypermethrin plus deltamethrin plus Withania somnifera group and cypermethrin plus deltamethrin plus resveratrol group, both Withania somnifera and resveratrol co-treatment restored the changes to normal observed following combined cypermethrin and deltamethrin exposure in rats. The present study showed that combined cypermethrin and deltamethrin exposure caused histopathological changes which is reversed and restored to normal following co-treatment with Withania somnifera and resveratrol. This indicates the ameliorating effects in rats exposed to cypermethrin and deltamethrin.