Vol. 8, Issue 1 (2019)

Author(s):
Robin, SK Jain, Pooja Kundu, Nikita and Vikas Godara

Abstract:
The combined exposure of cypermethrin and deltamethrin was given in adult male Wistar rats and their amelioration by Withania somnifera and resveratrol on haematological alterations was investigated up to 28 days. The combined treatment of cypermethrin and deltamethrin caused significant decrease in total erythrocyte count, total leucocyte count, haemoglobin, packed cell volume, mean corpuscular haemoglobin and mean corpuscular haemoglobin concentration. It caused increase in neutrophil count and decrease in lymphocyte count. In the cypermethrin plus deltamethrin plus Withania somnifera group and cypermethrin plus deltamethrin plus resveratrol group, both Withania somnifera and resveratrol co-treatment restored the changes to normal observed following combined cypermethrin and deltamethrin exposure in rats. The present study showed that combined cypermethrin and deltamethrin exposure cause haematological alterations in rats which is reversed and restored to normal values following co-treatment with Withania somnifera and resveratrol. This indicates the ameliorating effects in rats exposed to cypermethrin and deltamethrin.