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Vol. 8, Issue 1 (2019)

In vivo antidepressant, analgesic, anti-inflammatory activities, in vitro antioxidant and antibacterial potential of fractionated Elatostema papillosum Wed. extrac

Author(s):
Md. Zia Uddin, Talha Bin Emran, Mycal Dutta, SM Amanat Ullah, Shahadat Hossain and Md. Sohel Rana
Abstract:
The study was conducted to evaluated the in vivo CNS antidepressant, analgesic, anti-inflammatory, in vitro antioxidant and antibacterial activities of crude methanol extract with its petroleum ether soluble fraction (PESF), carbon tetrachloride soluble fraction (CTCSF), chloroform soluble fraction (CSF) and aqueous soluble fraction (AQSF) of Elatostema papilosum wed. On investigation it was found that crude methanol extract (34 ± 1.76 mins) and its CSF fraction (48 ± 1.13 mins) showed statistically significant (P<0.05) antidepressant activity by increasing phenobarbitone induced sleeping time of mice, produced significant (P<0.05) inhibition in abdominal writhes produced by acetic acid and the degree of inhibition were (24.80 ± 3.32)% and (29.18 ± 2.33)% respectively whereas produced significant (P<0.05) anti-inflammatory effect of (48.13 ± 3.18)% and (54.54 ± 3.78)% respectively after 1st hour of carrageenan injection. It was also observed that methanol extract and its CS fraction showed statistically significant (P<0.01) DPPH free radical scavenging activity with IC50 value of 15.14 ± 0.33 µg/ml and 18.45 ± 0.18 µg/ml respectively as well as methanol extract showed 25.1, 21.1, 27.4 and 24.3 mm of diameter of zone of inhibition against four tested gm (+) ve bacteria whereas CS fractions showed 22.3, 24.6, 26.3 and 21.6 mm respectively. Similarly, PES fraction (39 ± 1.80 mins) showed significant (P<0.05) antidepressant activity, as well as significant (P<0.05) anti-inflammatory effect of (40.12 ± 3.75) % after 1st hour of carrageenan injection and showed 26.7 and 24.7 mm of diameter of zone of inhibition against Bacillus subtilis and Staphylococcus aureus.
Pages: 241-246  |  372 Views  25 Downloads
How to cite this article:
Md. Zia Uddin, Talha Bin Emran, Mycal Dutta, SM Amanat Ullah, Shahadat Hossain, Md. Sohel Rana. <em>I</em><em>n vivo</em> antidepressant, analgesic, anti-inflammatory activities, <em>in vitro</em> antioxidant and antibacterial potential of fractionated <em>Elatostema papillosum</em> Wed. extrac. Pharma Innovation 2019;8(1):241-246.
The Pharma Innovation Journal