Vol. 8, Issue 1 (2019)

Author(s):
Lisha V

Abstract:
Ischemia reperfusion (IR) injury is manifested in many ways from safer transient arrhythmias to fatal multiple organ dysfunction syndrome. Reperfusion injury is the damage of tissue that is caused when blood flow is restored to a region after certain period of ischemia Myocardial stunning, transplantation failure and organ dysfunction are some of its clinical outcomes. Several approaches, such as low-temperature reperfusion and ischemic preconditioning, are proven to be beneficial in animal models of IR injury. The purpose of this review article is to summarize its pathophysiology, clinical presentation as well as therapeutic strategies to limit ischemia-reperfusion injury.