Protective role of Excoecaria agallocha L. against streptozotocin induced diabetic complications
G Kiran, Ganesh N Sharma, Birendra Shrivastava and AMS Sudhakar Babu
Oxidative stress has a pivotal role in the pathogenesis and development of various diabetic-related complications, the most common and debilitating effects of diabetes mellitus are on kidney, liver and heart tissue. There is accumulating evidence that Excoecaria agallocha L extract, a rich source of phenolic and flavonoid components, has hypoglycemic and antioxidative properties. This study aimed to determine the protective effects of Excoecaria agallocha L extract against streptozotocin-induced diabetic complications on kidney, liver and heart in rat. The diabetic rat model was generated by intraperitoneal injection of streptozotocin (STZ) at a dose of 60 mg/kg, i.p. dissolved in 0.01M citrate buffer (pH 4.5) after 16 h fasting. A subset of the STZ-induced diabetic rats intragastrically administered with Excoecaria agallocha L. extract (250 and 500 mg/kg/day) before or after the onset of diabetes for 16 weeks, whereas other diabetic rats received only isotonic saline as the same volume of Excoecaria agallocha L extract. To evaluate the effects of Excoecaria agallocha L extract on the diabetic rats various parameters, including oxidative parameters, liver enzymes, kidney-specific parameters, and histopathology were assessed along with other biochemical assessments. Greater blood sugar, SGOT, SGPT, creatine kinase, urea whereas lower uric acid, creatinine and total protein were detected in the STZ-diabetic rats, which were significantly attenuated after Excoecaria agallocha L extract administration, dose-dependently. Even various oxidative stress parameters were also drastically changed in a STZ-diabetic rats which were improved by Excoecaria agallocha L extract. Histopathological study of liver, kidney and heart tissue were supported the potential protective effect of Excoecaria agallocha L extract. The activity elicited by the extract might be due to its ability to activate antioxidant enzymes. The findings suggest the potential use of the extract of Excoecaria agallocha L. as a novel therapeutically useful nephron protective, hepatoprotective and cardio protective agent.
How to cite this article:
G Kiran, Ganesh N Sharma, Birendra Shrivastava, AMS Sudhakar Babu. Protective role of <em>Excoecaria agallocha</em> L. against streptozotocin induced diabetic complications. Pharma Innovation 2018;7(9):17-26.