Vol. 7, Issue 8 (2018)

Author(s):
Pawan Jalwal, Deepak, Shailja, Jyoti, Ajit, Gourav, Gurdev Singh, Sharad Sardana and Sunil Kumar

Abstract:
The study aimed to investigate the formulation, characterization, and antibacterial activity of Ofloxacin-loaded nanoparticles as potential drug delivery systems for the treatment of bacterial infections. Ofloxacin, a widely used fluoroquinolone antibiotic, suffers from limitations such as poor aqueous solubility and rapid clearance, which can compromise its therapeutic efficacy. Nanoparticle-based drug delivery systems offer a promising solution to overcome these challenges by enhancing drug solubility, prolonging drug release, and improving bioavailability. In this study, Ofloxacin-loaded nanoparticles were prepared using a nanoprecipitation method and characterized for their physicochemical properties, including size, morphology, and drug encapsulation efficiency. In vitro release studies were conducted to evaluate the release profile of Ofloxacin from nanoparticles, while antibacterial activity assays were performed to assess their efficacy against Staphylococcus aureus. The results demonstrated that Ofloxacin-loaded nanoparticles exhibited a uniform size distribution, high drug encapsulation efficiency, and sustained release of Ofloxacin over 24 hours. Additionally, the nanoparticles demonstrated potent antimicrobial activity against Staphylococcus aureus, with significantly larger zones of inhibition compared to free Ofloxacin solution. These findings highlight the potential of Ofloxacin-loaded nanoparticles as effective antimicrobial agents with prolonged drug release profiles, offering promising opportunities for the development of improved therapies for bacterial infections.