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Vol. 7, Issue 8 (2018)

Formulation & in-vitro evaluation of Domperidone soft chew

Author(s):
Ruheena Taranum and Sirisha Mittapally
Abstract:
Soft chews are popular in recent times due to increased patient acceptance as it include candy base with sweet taste. It is patient friendly dosage form for paediatric & dysphagic patients. Soft chews have been exploited for delivery of calcium & vitamin supplements to patients with vitamin deficiency & hypocalcaemia. In the present research work Domperidone soft chews were formulated in order to increase patient acceptance, faster onset of action & for quick relief from nausea & vomiting compared to conventional dosage forms due to chewing effect drug is immediately released in saliva & most of it is absorbed in systemic circulation. Solubility of Domperidone was enhanced by complexation with cyclodextrins. Soft chew is prepared from sucrose, liquid glucose, milk cream, inter esterified vegetable fat & soya lecithin by heating & congealing method. It is evaluated for appearance, weight variation, drug content, & dissolution. The optimized formulation showed a drug release of 95.8% in 25mins using simulation method. Stability study was carried out at 30º±2ºC/65% RH± 5% for 3months & has shown satisfactory result.
Pages: 424-431  |  226 Views  6 Downloads
How to cite this article:
Ruheena Taranum, Sirisha Mittapally. Formulation &amp; <em>in-vitro</em> evaluation of Domperidone soft chew. Pharma Innovation 2018;7(8):424-431.
The Pharma Innovation Journal