Vol. 7, Issue 8 (2018)
Cardiopulmonary response following administration of buprenorphine and butorphanol in cats anaesthetized with midazolam-ketamine-isoflurane
Dharmaceelan S, Ramakrishnan KS, Senthilkumar S, Vijayakumar G and Rajendran N
Clinical study was conducted to access the cardiovascular effect of buprenorphine and butorphanol in 18 female cats anaesthetized with midazolam-ketamine- isoflurane. The cats were divided in to three Groups. In Group I, anaesthesia was induced by midazolam (@0.3mg/kg) ketamine (11mg/kg) mixture. In Group II and Group III cats, butorphanol and buprenorphine were administered @ 0.4 mg/kg and 0.01 mg/kg, 15 minutes prior to induction as in Group I and maintained with isoflurane. Pulse rate, Respiration rate, saturation of peripheral oxygen (SPO2), inspired fraction of oxygen (FiO2), end tidal oxygen (ETO2), inspired fraction of carbon dioxide (ETCO2), end tidal carbon dioxide and electrocardiography were recorded. A significant (p<0.05) increase in pulse rate during 5, 10 and 30th min. after induction in group III was observed. Statistical comparison revealed no significant change in the FiO2, ETO2 and ETCO2. No life threatening cardiovascular emergencies were noticed during the ECG study.
How to cite this article:
Dharmaceelan S, Ramakrishnan KS, Senthilkumar S, Vijayakumar G, Rajendran N. Cardiopulmonary response following administration of buprenorphine and butorphanol in cats anaesthetized with midazolam-ketamine-isoflurane. Pharma Innovation 2018;7(8):339-341.