Vol. 7, Issue 8 (2018)

Author(s):
Pavlovskyi Sergii A

Abstract:
The use of S-adenosylmethionine in the treatment of 25 patients with non-alcoholic fatty liver disease (group 1) had high efficacy with the normalization of the functional, biochemical and cytokine profile of the blood. With the use of diabetic and pioglitazone in 25 patients in group 2, the cytolysis, mesenchymal-inflammatory syndrome, cytology, hemograms, and lipid metabolism have been stabilized, which confirms the positive lipidotrophic effect of the complex effects of diabetone and pioglitazone on the functional state of hepatocytes and indicates a decrease in insulin resistance and improving the function of B cells. Integrated therapy with combined hypoglycemic and lipotropic therapy (diabetic, pioglitazone, geptral, group 3, 30 patients) showed the most pronounced anti-inflammatory effect. Pain syndrome remained tangible in 9 patients (30%, 1.8 times less than before treatment); dyspeptic syndrome-in 10 patients (33,3%, decreased by 1,7 times), appetite decreased – in 10 patients (33,3%, a decrease of 1,9 times), astenovegetative syndrome-in 11 patients (36,7 %, decrease by 1.9 times). The applied combined hypoglycemic and lipotropic therapy on the background of basic therapy positively influenced the state of hepatocytes: the activity of ALT decreased to (0.61 ± 0.03) μmol/l, AST (0.52 ± 0.04) μmol/l, alkaline phosphatase - (78,18 ± 2,21) units/l, gammaglutamyltranspeptidases-up to (52,34 ± 1,26) unit/l, (the difference between pre and post treatment is likely, p<0,05). During the ultrasound study, the redistribution of the number of patients in the side with the reduction of heavier stages of hepatosis, compared with the state of treatment. Particularly important is a significant decrease in the number of patients with the third stage of hepatosis with a decrease in the content of FNP-a, IL-6 and C-reactive protein and the growth of adiponectin.