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Vol. 7, Issue 8 (2018)

Formulation, development and evaluation of controlled porosity osmotic tablet of Vildagliptin

Author(s):
Komal Pangavhane and Ravindranath Saudagar
Abstract:
The present work aims towards the development of controlled release formulation of water soluble drug Vildagliptin based on osmotic technology by using controlled porosity approach. Vildagliptin is anti-diabetic drug with short half-life, makes the development of controlled release dosage forms extremely advantageous. A present work comprises a drug Vildagliptin, NaCl, HPMC, Magnesium Stearate, Lactose, PVP K30, Talc, Cellulose acetate, PEG 400. NaCl was used as an osmogent and HPMC K100M was used as a release retardant. Cellulose acetate was used as the semipermeable membrane and PEG 400 was used as pore forming agent. Optimization was done using 32 factorial design considering two independent variable at three levels. Optimized formulation (F8) exhibited zero order kinetics with a drug release of 98.84% in 24hrs. Scanning electron microscope study showed the formulation of pores in membrane. It was concluded that release of Vildagliptin was significantly controlled from controlled porosity osmotic drug delivery system.
Pages: 187-191  |  1009 Views  213 Downloads


The Pharma Innovation Journal
How to cite this article:
Komal Pangavhane, Ravindranath Saudagar. Formulation, development and evaluation of controlled porosity osmotic tablet of Vildagliptin. Pharma Innovation 2018;7(8):187-191.

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