Vol. 7, Issue 7 (2018)

Author(s):
Pandeti Akhil, Sasikanth Kothamasu, Suryakanta Swain and Manohar Babu S

Abstract:
In the present study, Enalapril maleate (EM) loaded solid lipid microparticles (SLMs) were successfully prepared using cetostearyl alcohol (CA) and carnauba wax (CW) by fusion and emulsion congealing method to achieve controlled release for oral administration. SLMs were prepared at different drug: polymer ratios of 1:3, 1:5, and 1:7 w/w. The SLMs prepared by both methods were found to be fine and free flowing and percentage yield of all the formulations was found to be satisfactory. Drug content of all prepared SLMs was uniform indicated by the low SD values. Microencapsulation efficiency was high with SLMs prepared with CW than with CA. The FT-IR studies confirmed no interaction between the drug and polymers. The size of SLMs prepared with CA and CW were distributed in the range of 393.25 nm to 413.53 nm and 342.29 nm to 373.67 nm respectively. The in vitro dissolution studies showed that, the release of EM was sustained and prolonged up to 8 h from SLMs prepared with both polymers. The drug release from CA-SLMs and CW-SLMs was found to be decreased with increase in polymer concentration. The over all in vitro results indicated that, SLMs of CA and CW prepared by emulsion congealing method gave higher rate of drug release compared to SLMs prepared by fusion method. All prepared SLMs reflects the vital role of lipid polymers ie., cetostearyl alcohol and carnauba wax as drug release retardants to formulate oral controlled drug delivery systems of Enalapril maleate to improve therapeutic efficacy and patient compliance.