Vol. 7, Issue 7 (2018)

Author(s):
Kusumpudi Swapna, Sasikanth Kothamasu, Suryakanta Swain and Manohar Babu S

Abstract:
Gliclazide Sustained release tablets were prepared by Direct Compression method using different polymers HPMC & Eutragit and combination of both show drug release in a sustain manner. Various solid matrix formulations were prepared with swellable and non-swellable polymers (HPMC K100CR, Eudragit L-100) in solid matrix using direct compression method. In the dissolution studies of all formulations, the formulation containing HPMC alone that is F1, F2, F3, F4 show 95% dissolution but shows fluctuations. The formulation containing Eudragit that is F5, F6, F7, F8 doesn’t show better dissolution profile. In F3, F8, F9 formulations the first two formulations release of drug is completed within 8 to 10 hours. The later formulation gives a drug release in a sustain manner. The formulation F9, drug release profile is 99%, rest of all formulations. In the formulation F9 having swellable polymer HPMC K100CR and non-swellable polymer (Eudragit L-100) showing better drug release profile. Hence the combination of both polymers are better suitable for sustained release delivery. Thus, formulation F9 having both HPMC and Eudragit polymers in the ratio of 1:1 show 99% drug release for prolong time.