Vol. 7, Issue 7 (2018)

Author(s):
Kota Raveendhra, Sasikanth Kothamasu, Suryakanta Swain and Manohar Babu S

Abstract:
The objective of present study was to develop controlled release topical gel of baclofen 0.5%w/w using hydrophilic polymers such as Carbopol, Xanthum, Carrageenan, Sodium alginate etc as gelling agents. Results revealed that prepared gel systems showed good physical characteristics, no drug-polymer interaction and no skin irritation was observed. The F13 formulation was found to be stable as there was no drastic change in the physicochemical properties. Thus conclusion can be made that stable topical hydrogels of baclofen has been developed. F13, F7 formulations showed highest cumulative percentage drug release of 98.98%, 96.46% were obtained during in vitro drug release studies after 24 hrs and F18 formulation showed 99.74% after 22 hr. The release of baclofen appears to be dependent on concentration of polymer. High viscous polymeric network showed showed best release. High viscosity of the gel system acts as a barrier in between the drug and site of absorption (skin). During the in vitro drug permeation study conducted on F13, F17 and F18 formulation showed cumulative amount of drug permeation of 662.87, 659.19, 661.20 µg/cm^2/hr respectively. The ex vivo skin permeation studies were conducted on F13, F17and F18 formulations, the F13 formulation exhibited high (662.87) cumulative amount of drug permeation through abdominal rat skin when compare with other formulations i.e. F17(649.47), F18(659.96). The F13 formulation showed flux of 4.2743 µg/cm²/hr with permeability coefficient of Kp 1.4247. Based upon the in vitro dissolution data and in vitro drug permeation data the F13, F17 and F18 formulations showed similar drug release but upon ex vivo permeation studies it was found that F13 formulation showed superior drug release, therefore F13 formulation was concluded as optimized formulation.