Vol. 7, Issue 7 (2018)

Author(s):
Valentyna Goncharuk, Iryna Savelikhina and Kseniia Ostrovska

Abstract:
Chronic obstructive pulmonary disease (COPD) is a pathologic pulmonary condition characterized by expiratory airflow obstruction due to emphysematous destruction of the lung parenchyma and remodeling of the small airways. COPD is now recognised to be a condition of global importance because of high morbidity and risk of premature death of millions of people. Chronic inflammation and exacerbations play a central role in the progression of the disease. Roflumilast – a phosphodiesterase-4 (PDE4) inhibitor, through selective inhibition of the PDE4 enzyme, roflumilast prevents the breakdown of cyclic AMP, which plays an important role in regulating inflammatory cell activity.