The aim of the present study was to evaluate antidiabetic activity of aqueous extract of
seeds in streptozotocin (STZ) induced diabetic rats.
Methods: Linum usitatissimum
seeds extract or glibenclamide was administered to the rats orally daily for 28 days. Levels of blood glucose at weekly interval and on 29th day various hematological parameters, serum biochemical parameters as well as histopathology were carried out to evaluate its antidiabetic effects in diabetic rats.
Results: Blood glucose, creatinine, BUN, AST, ALT and total cholesterol levels were significantly increased along with alterations in pancreas tissues in STZ induced diabetic rats as compared to vehicle control rats. After 28 days administration of aqueous extract Linum usitatissimum showed the significant decrease in above levels along with no defined pathological lesions in histoarchitecture of pancreas as compared to diabetic control rats.
Conclusion: Our results suggest that the aqueous extract of Linum usitatissimum seeds clearly demonstrated the antidiabetic activity in an experimental model of rats.