Vol. 7, Issue 7 (2018)

Author(s):
Archana Gorle and Chhaya Gadgoli

Abstract:
Present study focuses on the hypoglycemic activity of poly herbal formulation (PF) with and without piperine in STZ induced diabetic rat model. Poly herbal formulation contain the dried 70% aqueous ethanolic extract of herbs Pterocarpus marsupium, Gymnema sylvestre, Trigonella foenumgrecum, Momordica charantia and piperine from Piper nigrum as bioenhancer. Diabetes was induced by streptozotocin (60 mg/kg, i.p.) and poly herbal formulation was given with and without piperine (250 and 500 mg/kg) for 14 days in the separated groups. The effect of the polyherbal formulation on blood glucose levels was studied at regular intervals. At the end of the study, the blood samples were collected from all the animals for biochemical estimation. Result of the study suggested that there was significant decrease in the blood glucose level in STZ+PF (250 and 500 mg/kg) with piperine than negative control group and STZ+PF (250 and 500 mg/kg) without piperine. Moreover treatment with PF with piperine significantly decreases BUN, creatinine and triglyceride level than negative control group. Present study concludes that polyherbal formulation developed with bienhancer (piperine) showed more potent antidiabetic activity in same dose compare to without piperine formulation.